Critical limb ischemia (CLI), also referred to as
limb threat, is an advanced stage of
peripheral artery disease. It includes ischemic
rest pain,
arterial insufficiency ulcers, and
gangrene. The latter two conditions are jointly referred to as
tissue loss, reflecting the development of surface damage to the limb
tissue due to the most severe stage of
ischemia. CLI has a negative prognosis within a year after the initial diagnosis, with 1-year amputation rates of approximately 12
nd mortality of 50
t 5 years and 70
t 10 years.