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Additional
germinal center
English Wikipedia - The Free Encyclopedia
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Germinal center
Germinal centers
or
germinal centres
(GC) are sites within
secondary lymphoid organs
where mature
B lymphocytes
proliferate, differentiate, and mutate their antibody genes (through
somatic hypermutation
), and
switch the class of their antibodies
(for example from
IgM
to
IgG
) during a normal immune response to an infection. They develop dynamically after the activation of
follicular (Fo) B cells
by T-dependent
antigen
.
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