Hypervitaminosis E is a state of
vitamin E toxicity. Since vitamin E can act as an
anticoagulant and may increase the risk of bleeding problems, many agencies have set a tolerable upper intake levels (UL) for vitamin E at 1,000 mg (1,500 IU) per day. This UL was established due to an increased incidence of hemorrhaging with higher doses of supplemental vitamin E. Doses of vitamin E above the UL can also magnify the
antiplatelet effects of certain drugs such as anti-coagulant medications and
aspirin, which can cause life-threatening symptoms in ill patients. Hypervitaminosis E may also counteract
vitamin K, leading to a
vitamin K deficiency.