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Additional
leukotriene B4
English Wikipedia - The Free Encyclopedia
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Leukotriene B4
Leukotriene B4
is a
leukotriene
involved in
inflammation
. It is produced from
leukocytes
in response to inflammatory mediators and is able to induce the adhesion and activation of leukocytes on the
endothelium
, allowing them to bind to and cross it into the tissue. In
neutrophils
, it is also a potent
chemoattractant
, and is able to induce the formation of
reactive oxygen species
and the release of
lysosomal
enzymes by these cells. It is synthesized by
leukotriene-A4 hydrolase
from
leukotriene A4
.
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