Nucleotidyltransferases are
transferase enzymes of phosphorus-containing groups, e.g.,
substituents of nucleotidylic acids or simply
nucleoside monophosphates. The general reaction of transferring a nucleoside monophosphate moiety from A to B, can be written as:
- A-P-N + B A + B-P-N
For example, in the case of polymerases, A is pyrophosphate and B is the nascent polynucleotide. They are classified under
EC number 2.7.7 and they can be categorised into:
- Uridylyltransferases, which transfer uridylyl- groups
- Adenylyltransferases, which transfer adenylyl- groups
- Guanylyltransferases, which transfer guanylyl- groups
- Cytitidylyltransferases, which transfer cytidylyl- groups
- Thymidylyltransferases, which transfer thymidylyl- groups