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Additional
thiamine pyrophosphate
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Thiamine pyrophosphate
Thiamine pyrophosphate
(TPP or ThPP), or
thiamine diphosphate
(ThDP), or
cocarboxylase
is a
thiamine
(vitamin B
1
)
derivative
which is produced by the
enzyme
thiamine diphosphokinase
. Thiamine pyrophosphate is a
cofactor
that is present in all living systems, in which it catalyzes several
biochemical
reactions. It was first discovered as an
essential nutrient
(
vitamin
) in humans through its link with the
peripheral nervous system
disease
Beriberi
, which results from a deficiency of thiamine in the
diet
.
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