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von Willebrand factor
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Von Willebrand factor
Von Willebrand factor
(vWF) is a
blood
glycoprotein
involved in
hemostasis
. It is deficient or defective in
von Willebrand disease
and is involved in a large number of other diseases, including
thrombotic thrombocytopenic purpura
,
Heyde's syndrome
, and possibly
hemolytic-uremic syndrome
. Increased plasma levels in a large number of cardiovascular, neoplastic, and connective tissue diseases are presumed to arise from adverse changes to the
endothelium
, and may contribute to an increased risk of
thrombosis
.
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